Spravato Treatment for Depression

In-Clinic Spravato Treatment in Minnesota, Wisconsin, and South Dakota

Exploring a different approach to depression treatment

Trying different medications or treatments without finding enough relief can be frustrating. Spravato is a prescription esketamine nasal spray that may be considered for adults with treatment-resistant depression. Treatment takes place in a monitored clinic setting. Our team helps patients understand whether Spravato may be appropriate, what insurance may require, and what to expect throughout treatment.

What is Spravato (esketamine)?

Spravato is an FDA-approved prescription nasal spray containing esketamine. It may be considered for adults with treatment-resistant depression who have not improved enough after trying other antidepressant medications.

Spravato works differently from traditional antidepressants by affecting a chemical messenger in the brain called glutamate, which may help reduce depression symptoms for some patients.

Who May Be Considered For Spravato?

Spravato may be considered for adults who:

Have depression that has not improved enough with antidepressant medication
Have tried more than one medication without finding relief
Continue to experience symptoms that affect daily life
Are interested in exploring another treatment option

Spravato is not appropriate for everyone. Before recommending treatment, our team will review your symptoms, health history, medications, previous treatments, and individual needs.

SPRAVATO Vs. IV Ketamine: What is the difference?

Spravato and IV ketamine are related treatments, but they are not the same. Both are provided in a monitored clinic setting, but they use different forms of medication and are given differently.

Spravato

Spravato contains esketamine and is used as a nasal spray. You administer the spray yourself under the supervision of our care team and remain at the clinic for monitoring afterward. Spravato is FDA-approved for certain adults with depression and must be provided through a SPRAVATO® REMS-certified treatment setting.

IV Ketamine

IV ketamine is delivered directly into a vein through an infusion. Although ketamine is an FDA-approved medication, its use for depression is considered off-label. Your provider monitors you throughout the infusion and recovery period.

Neither treatment is automatically the right choice for every patient. Your provider can review your symptoms, health history, previous treatments, insurance coverage, and preferences to help determine which options may be appropriate.

SPRAVATO TREATMENT AT THE REMEDY MENTAL HEALTH

Initial Evaluation

Your provider reviews your symptoms, health history, medications and previous treatments.

Insurance & Eligibility Review

Our team will review your insurance information and any prior-authorization requirements.

Before Treatment

Explain preparation, transportation, and appointment-day instructions and ensure you are ready for treatment.

During the Appointment

You will use the Spravato nasal spray under staff supervision. After treatment, you will remain at the clinic for at least two hours for monitoring.

Ongoing Treatment

Our team checks your comfort and progress throughout treatment. Your provider will discuss follow-up care and any recommended next steps.

Ready to take the next step? Our team can help match you with the right provider.

WHY CHOOSE THE REMEDY MENTAL HEALTH?

The Remedy provides support throughout the entire Spravato process, from your initial evaluation and insurance review to treatment clearance and ongoing appointments. As a SPRAVATO® REMS-certified treatment setting, we follow the required safety and monitoring guidelines for providing Spravato in the clinic. Our team helps patients understand what to expect, answers questions throughout treatment, and coordinates care based on each person’s individual needs.

Because The Remedy also offers psychiatry, medication management, therapy, and other advanced treatment options, your provider can consider Spravato as part of your overall mental health care. Treatment is available at select clinics across Minnesota, Wisconsin, and South Dakota.

MEET OUR SPRAVATO PROVIDERS

Our Spravato providers offer personalized evaluations, treatment planning, and ongoing support throughout your course of care.

SPRAVATO TREATMENT NEAR YOU

The Remedy Mental Health provides care across Minnesota, Wisconsin and South Dakota. Our clinics provide Spravato treatment in the Twin Cities, Minneapolis, St. Paul, Burnsville, Golden Valley, Maple Grove, Vadnais Heights, Eau Claire, Hudson, Rapid City and surrounding communities.

QUESTIONS ABOUT SPRAVATO

Does insurance cover Spravato?

Insurance may cover Spravato, but coverage and out-of-pocket costs vary by plan. Prior authorization is often required, and your insurance company may request information about your diagnosis and previous depression treatments.

Our team will review your benefits, explain any insurance requirements, and submit the necessary information before treatment begins. Final approval and costs, including any deductible, copay, or coinsurance, are determined by your insurance company.

Do I need a referral for Spravato?

No, you do not need a referral to contact The Remedy about Spravato treatment. Our team can help you get started, schedule an evaluation, and determine whether Spravato may be appropriate for you. Some insurance plans may have their own requirements before treatment is approved.

What might I feel during Spravato treatment?

Each person’s experience is different. During or shortly after treatment, you may feel sleepy, dizzy, lightheaded, relaxed, or slightly disconnected from yourself or your surroundings. Some people experience changes in how things look, sound, or feel, while others notice very little. Nausea, anxiety, or a temporary increase in blood pressure may also occur.

Our team will monitor you throughout your appointment and check in on how you are feeling. These effects commonly begin soon after treatment and often lessen before you leave the clinic.

Can I drive after treatment?

No. You will need to arrange for someone to drive you home after each Spravato appointment. You should not drive, operate machinery, or do anything that requires your full attention until the next day after a restful night of sleep—even if you feel well enough to do so.

What is the treatment schedule for Spravato?

Spravato treatment typically begins with two appointments per week for the first four weeks. After that, treatment may continue once per week or every other week, depending on your response and individual treatment plan.

Your provider will review your progress and determine how often treatment should continue. Insurance requirements may also affect the approved schedule.

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